Extrinsic blood coagulation pathway and risk factors for thrombotic events in patients with essential thrombocythemia
نویسندگان
چکیده
منابع مشابه
Thrombotic risk assessment in 185 WHO-defined essential thrombocythemia patients: single center experience
Thrombosis risk in essential thrombocythemia (ET) patients can be assessed using different prognostic systems. Conventional risk factors include age more than 60 years and history of previous thrombosis. In addition, other factors such as JAK2 V617F mutations, cardiovascular risk factors, leukocytosis more than 11 × 10(9)/l, thrombophilic factors and platelet count more than 1500 × 10(9)/l are ...
متن کاملextrinsic and intrinsic coagulation pathway, fibrinogen serum level and platelet count in hiv positive patients.
infection with human immunodeficiency virus (hiv) is a progressive condition which may cause endothelial dysfunction and liver damage leading to coagulopathy. with adventure of highly active antiretroviral therapy (haart), life expectancy has prolonged in hiv positive patients but several acquired immunodeficiency syndrome (aids)-related conditions such as coagulopathies are responsible for ass...
متن کاملThe expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia.
Using immunohistochemistry, we investigated the expression of c-mpl in bone marrow megakaryocytes of 88 patients with essential thrombocythemia (ET), 6 patients with secondary thrombocytosis (ST), and 20 patients with lymphoma (controls). Considering both the pattern of expression and the staining intensity, we identified a uniform and a heterogeneous pattern of c-mpl expression. The uniform pa...
متن کاملJAK2 mutation status, hemostatic risk factors and thrombophilic factors in essential thrombocythemia (ET) patients.
The recently discovered JAK2 V617F point mutation, found in 50-60% of ET patients, has been reported to be associated with a higher risk of thrombotic events. In this study, we explored if JAK2 V617F mutation, or coexisting thrombophilic and hemostatic risk factors, contributed to these complications. We examined 32 patients with ET, and looked for pathogenetic JAK2 V617F mutation and prothromb...
متن کاملAn alternative extrinsic pathway of human blood coagulation.
To study the interrelationships of the major human coagulation pathways, factor X activation in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin were added to plasma samples containing 3H-labeled factor X, and the time course of factor X activation was determined. At a 1/250 dilutio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Polish Archives of Internal Medicine
سال: 2016
ISSN: 1897-9483
DOI: 10.20452/pamw.3429